Albendazole vs. Other Antiparasitics: What You Need to Know

Looking for the right drug to kick out intestinal worms? Albendazole is a popular choice, but it’s not the only game in town. In this guide we break down how Albendazole measures up against the most common alternatives, so you can pick the one that fits your needs.

How effective is Albendazole compared to the rest?

Clinical data shows Albendazole clears most common helminths—like Ascaris, hookworm, and Trichuris—in a single 400 mg dose. Mebendazole, a close cousin, needs a 100 mg dose twice daily for three days to reach the same cure rates for some parasites. For stronger infections such as neurocysticercosis, doctors often prefer Albendazole because it penetrates brain tissue better.

When it comes to muscle‑invasive parasites like Strongyloides, both drugs work, but Albendazole’s longer half‑life gives it a slight edge. In short, if you want a quick, one‑shot solution, Albendazole usually wins.

Safety, side effects, and price – the practical stuff

Both Albendazole and Mebendazole share a similar safety profile: mild nausea, abdominal pain, or headache in a small number of users. Serious liver issues are rare but more reported with long‑term Albendazole use, so a short course is safest for most people.

Cost can tip the balance. Generic Albendazole often costs $5‑$10 for a 400 mg tablet in the U.S., while Mebendazole is usually a bit cheaper per dose. If you need a pediatric formulation, Mebendazole is widely available as a chewable tablet, whereas Albendazole is mostly pills.

Another competitor is Ivermectin, which targets a different set of parasites (like scabies and certain lice). Ivermectin is not interchangeable with Albendazole for intestinal worms, but it is useful when co‑infection is suspected.

Bottom line: Albendazole offers a strong cure rate in a single dose, with modest side effects. It’s a bit pricier than Mebendazole but saves you from taking multiple pills over several days.

Whatever you choose, always follow your doctor’s prescription and finish the full course. Skipping doses can let parasites survive and become resistant.

Need a quick recap? Albendazole is best for single‑dose, broad‑spectrum worm treatment; Mebendazole is a cheaper, multi‑day option; Ivermectin is a specialist drug for skin‑related parasites. Talk to your healthcare provider to decide which fits your situation best.

Albendazole vs Alternatives: Choosing the Best Antiparasitic

A concise guide comparing Albendazole with mebendazole, ivermectin, praziquantel, and more, covering effectiveness, side effects, cost, and best use cases.

Written by

Vinny Benson, Sep, 28 2025